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  • Title: Molecular analysis of the t(1;19)(q23;p13) translocation observed in adult leukemias.
    Author: Mitani K, Sasaki K, Ogawa S, Hayashi Y, Mano H, Yazaki Y, Hirai H.
    Journal: Int J Hematol; 1994 Dec; 60(4):267-71. PubMed ID: 7894030.
    Abstract:
    We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19) by RNA-based polymerase chain reaction. This patient survived for 8 months only from the time of his diagnosis. On the other hand, the other two cases were negative for the E2A/PBX1 fusion and one of them with ALL remains in remission. Our observations suggest that there could be heterogeneity in the molecular events among adult leukemias carrying the t(1;19) and that the E2A/PBX1 fusion formation might also be associated with an adverse treatment outcome in adult leukemias as in childhood leukemias.
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