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  • Title: [Behavior of adult mice of various strains after exposure of thiophosphamide during organogenesis].
    Author: Lil'p IG, Bizikoeva FZ, Poletaeva II, Ivanov VI.
    Journal: Genetika; 1995 Jan; 31(1):101-10. PubMed ID: 7896120.
    Abstract:
    Females of strains 101/HY and CBA were treated with a single dose of thio-TEPA (0, 0.625, or 1.25 mg/kg body weight) on day 12 of gestation (deposition of a vaginal plug was considered as the first day of gestation). Special experiments were performed on their offspring at 3 months of age to study exploratory-research activity (burrow reactions, upright postures), locomotor activity in a "open field" cage, emotional reactivity, and level of feeding motivation. Changes in behavior after exposure to thio-TEPA were observed in mice of both sexes and genotypes; however, in 101/HY mice, which are characterized by genetically determined genome instability and a defect in DNA repair system, such changes were more pronounced. In general, they may be defined as a decrease in intensity of exploratory-research activity with some modulation of the level of motor activity. Sex differences in behavior of animals of both strains after prenatal exposure to thio-TEPA were also found. The data provide evidence about the specific role of genetic factors in variation of mouse behavior after prenatal exposure to thiophosphamide and allow consideration of thio-TEPA as a behavioral teratogen.
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