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  • Title: Effect of chloroquine on rat liver mitochondria.
    Author: Deepalakshmi PD, Parasakthy K, Shanthi S, Devaraj NS.
    Journal: Indian J Exp Biol; 1994 Nov; 32(11):797-9. PubMed ID: 7896309.
    Abstract:
    Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.
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