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  • Title: Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis.
    Author: Roux S, Grossin M, De Bandt M, Palazzo E, Vachon F, Kahn MF.
    Journal: J Neurol Neurosurg Psychiatry; 1995 Mar; 58(3):363-6. PubMed ID: 7897423.
    Abstract:
    Angiotropic large cell lymphoma (ALCL), the so-called malignant angioendotheliomatosis, is characterised by proliferation of tumorous cells within small vessels. Manifestations in the CNS and cutaneous lesions prevail in the clinical presentation, although any organ can be involved. The recent classification of this lymphoma as part of the large cell lymphomas has modified the therapeutic approaches employed. This should improve the prognosis of this usually fatal disease. An unusual case presenting with fever, mononeuritis multiplex, and cutaneous lesions is reported. Peripheral neuropathy without other neurological symptoms is uncommon, and, to our knowledge, such isolated mononeuritis multiplex with nerve lesions has not been previously reported in ALCL. The clinical diagnosis was a systemic necrotising vasculitis and it is considered that its differential diagnosis must include angiotropic large cell lymphoma.
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