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  • Title: Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.
    Author: Aktories K.
    Journal: Mol Cell Biochem; 1994 Sep; 138(1-2):167-76. PubMed ID: 7898461.
    Abstract:
    The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years. Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization. Clostridium botulinum exoenzyme C3 and Clostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of the actin cytoskeleton. ADP-ribosylation inactivates the regulatory Rho proteins and disturbs the organization of the actin cytoskeleton.
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