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  • Title: Prenatal diagnosis of congenital human cytomegalovirus infection.
    Author: Nicolini U, Kustermann A, Tassis B, Fogliani R, Galimberti A, Percivalle E, Grazia Revello M, Gerna G.
    Journal: Prenat Diagn; 1994 Oct; 14(10):903-6. PubMed ID: 7899265.
    Abstract:
    Fifteen fetuses at risk of congenital human cytomegalovirus (HCMV) infection underwent prenatal diagnosis at 16-30 weeks' gestation by a combination of amniocentesis and fetal blood sampling. HCMV was isolated from the amniotic fluid in six patients, but HCMV-specific IgM was detected in only three of them. Two of the nine neonates, who were delivered following a negative prenatal diagnosis, had congenital HCMV infection diagnosed by virus isolation in the urine. The interval from infection to prenatal testing was 3 and 4 weeks in the two false-negative cases and > or = 7 weeks in the true-positive cases. Although timely testing for HCMV infection allows the option of termination of pregnancy, it may be flawed by false-negative results.
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