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  • Title: [Determination of tetramethylpyrazine and borneol in human plasma by GC-MSD].
    Author: Yang LL, Yuan YS, Tong YL, Guo CY.
    Journal: Yao Xue Xue Bao; 1994; 29(9):697-701. PubMed ID: 7900539.
    Abstract:
    A GC-MSD method for the determination of tetramethylpyrazine (TMP) and borneol in plasma is described. TMP and borneol were extracted with hexane-dichloromethane (10:1, V/V). Camphor was used as the internal standard. The average recoveries of TMP and borneol were 87.38% and 97.32% with relative standard deviation 1.90% to 6.21%, respectively. The method was successfully used to determine plasma borneol concentration following sublingual administration of 20 pills of Suxiao Jiuxin Wan to healthy volunteers (n = 10). The pharmacokinetic parameters have been listed in this paper.
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