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  • Title: Midbrain adrenergic mechanism modulating predatory attack behaviour induced by hypothalamic stimulation.
    Author: Saha S, Manchanda SK, Bhatia SC, Nayar U.
    Journal: Indian J Physiol Pharmacol; 1993 Apr; 37(2):121-6. PubMed ID: 7901160.
    Abstract:
    The present study was carried out in ten cats which did not attack the rats spontaneously. Predatory attack on a rat was produced by lateral hypothalamic stimulation using mean current strength of 340-690uA. This attack was accompanied by minimal affective display and culminated in neck biting. It was found that norepinephrine (NE) when microinjected into dorsal periaqueductal gray (dPAG) region in doses of 2, 4 and 10ug significantly lowered the mean current strength required for the elicitation of predatory attack by hypothalamic stimulation. Microinjection of propranolol (Prop), a beta-blocker, within the same region in similar doses significantly blocked the response as indicated by the increase in current strength required to produce the response. Control injections of normal saline and propylene glycol failed to produce any change. These findings indicate that hypothalamically induced aggressive responses involves beta adrenoceptive mechanisms located in the dPAG.
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