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  • Title: The effect of dapiprazole on accommodative amplitude in eyes dilated with 0.5 percent tropicamide.
    Author: Nyman N, Reich L.
    Journal: J Am Optom Assoc; 1993 Sep; 64(9):625-8. PubMed ID: 7901257.
    Abstract:
    BACKGROUND: Dapiprazole 0.5 percent (REV-EYES) eyedrops have recently become commercially available in the U.S. to reverse the diagnostic mydriasis produced by various concentrations and combinations of tropicamide and phenylephrine. Although a previous study has shown that dapiprazole increased accommodative amplitude after the administration of tropicamide, no attempt was made to control for differences in pupil size. METHODS: In the present single masked study, the accommodative amplitudes of forty-eight age-matched subjects previously dilated with 0.5% tropicamide were measured through a 3 millimeter artificial pupil following random instillation of dapiprazole in one eye and a placebo drop in the other eye. RESULTS: Area under the curve analysis determined that the magnitude of accommodative response to dapiprazole was significant at p < 0.001 (paired t-test). The McNemar test also showed that the accommodative amplitude was greater in eyes treated with dapiprazole at all observation points (p < 0.005), beginning at 15 mins after the instillation of the test drug. CONCLUSIONS: The results demonstrate that dapiprazole accelerates the return of accommodation independent of pupil size.
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