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  • Title: Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes.
    Author: Smyth RL, van Velzen D, Smyth AR, Lloyd DA, Heaf DP.
    Journal: Lancet; 1994 Jan 08; 343(8889):85-6. PubMed ID: 7903780.
    Abstract:
    We have observed five children with cystic fibrosis, who presented over 2 months, with meconium ileus equivalent that failed to respond to medical management. At surgery, four had a stricture in the ascending colon, and all had histopathological changes of post-ischaemic ulceration repair, with mucosal and submucosal fibrosis. The only common change in the management of these children was a switch from conventional enteric-coated pancreatic enzymes to high-strength products 12-15 months before presentation.
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