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  • Title: Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients.
    Author: Stein U, Wunderlich V, Haensch W, Schmidt-Peter P.
    Journal: Eur J Cancer; 1993; 29A(14):1979-81. PubMed ID: 7904171.
    Abstract:
    The expression of the mdr1 gene was evaluated at the RNA level by northern and slot blot analysis, and at the protein level by immunohistochemistry, in a total of 29 bone and 32 soft tissue sarcomas. All patients, mainly adults, had not received previous chemotherapy. Of the tumours investigated, 69% were mdr1-positive. An intermediate mdr1 expression was observed most frequently, with the exception of osteosarcomas (high) and malignant fibrous histiocytomas (low). Detection of P-glycoprotein in selected tumours revealed consistent results. However, no conclusion can be drawn as yet regarding correlation of mdr1 expression and drug resistance in patients.
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