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  • Title: Pharmacologic management of heart failure: neurohormonal agents.
    Author: Moser DK.
    Journal: Crit Care Nurs Clin North Am; 1993 Dec; 5(4):599-608. PubMed ID: 7905275.
    Abstract:
    Intense neurohormonal activation is characteristic of heart failure and contributes to the progression of ventricular dysfunction in this syndrome. Drugs that diminish neurohormonal arousal have a beneficial effect upon morbidity and mortality in chronic heart failure. The pathophysiology of neurohormonal activation in chronic heart failure is reviewed in this article to provide a basis for understanding intervention with agents that block the actions of the renin-angiotensin and sympathetic systems. Also covered is the description of the pharmacologic actions of these two classes of drugs and patient outcomes associated with their use.
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