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  • Title: Convulsant doses of cocaine alter immediate early gene and opioid peptide expression in rat limbic forebrain.
    Author: Helton TE, Daunais JB, McGinty JF.
    Journal: Brain Res Mol Brain Res; 1993 Nov; 20(3):285-8. PubMed ID: 7905595.
    Abstract:
    Rats were treated with escalating doses of cocaine until they experienced a convulsion and were euthanized 1 or 3 h after the last injection. Quantitative in situ hybridization histochemistry revealed that c-fos and zif/268 mRNAs were induced at 1 h in many limbic structures and declined 3 h after cocaine-induced convulsions. Preprodynorphin and preproenkephalin signals increased in many of the same structures 3 h, but not 1 h, after cocaine-induced convulsions.
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