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  • Title: Pancreatic secretion in man: effect of fasting, drugs, pancreatic enzymes, and somatostatin.
    Author: Anand BS, Goodgame R, Graham DY.
    Journal: Am J Gastroenterol; 1994 Feb; 89(2):267-70. PubMed ID: 7905706.
    Abstract:
    The inhibitory effect of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic-cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide, and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 micrograms bid given subcutaneously; increasing the dose up to 100 micrograms tid had no additional benefit. A stable pancreatic-cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
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