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  • Title: [The neuropeptide PACAP: its presence, its mode of action and its receptors].
    Author: Christophe J.
    Journal: Bull Mem Acad R Med Belg; 1993; 148(3-4):188-93. PubMed ID: 7906174.
    Abstract:
    Specific PACAP type I receptors show 200- 1000-fold higher affinity for both PACAPS as compared to VIP. Their occupancy stimulates adenylate cyclase and frequently also the inositol phosphate-calcium cascade. Considering a few PACAP-38 and PACAP-27 effects exerted on the hypothalamo-hypophyseal axis and elsewhere, there appears already that these neuropeptides may play a physiological role even more important than that of VIP.
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