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  • Title: Malignant aneuploid spindle-cell transformation in a proliferating trichilemmal tumour.
    Author: Alvarez-Quiñones M, Garijo MF, Fernández F, Val-Bernal JF.
    Journal: Acta Derm Venereol; 1993 Dec; 73(6):444-6. PubMed ID: 7906459.
    Abstract:
    A case of spindle-cell carcinoma developed on a proliferating trichilemmal tumour (PTT) is presented. The tumour on the scalp of an 84-year-old white woman was excised and histological examination showed typical features of PTT, but with a coexistent malignant spindle-cell tumour with a sarcomatoid appearance. There were some areas of transition between squamous trichilemmal epithelium and the neoplastic mass composed of atypical spindle-shaped cells. Two years later, the patient was well, and neither recurrence nor metastases were observed. We report the second case of PTT with a malignant spindle-cell transformation with a sarcomatoid appearance (spindle-cell carcinoma), and a proven aneuploidy, demonstrated with DNA-flow cytometric analysis.
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