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  • Title: [The effect of rilmenidine on the sympathetic activity of the renal nerve in waking barodenervated rats].
    Author: Maĭorov DN, Chernobel'skiĭ MA, Medvedev OS.
    Journal: Eksp Klin Farmakol; 1993; 56(6):19-21. PubMed ID: 7906579.
    Abstract:
    The effects of intracisternal pretreatment with alpha 2-adrenoceptor antagonists which possess imidazoline (idazoxan) or nonimidazoline (yohimbine) structures on the sympatho-inhibitory action of rilmenidine were investigated in conscious sinoaortic denervated rats. Intracisternal injection of rilmendine significantly decreased renal sympathetic nerve activity. Idazoxan pretreatment prevented the sympathoinhibitory action of rilmenidine, whereas yohimbine pretreatment failed. It is concluded that the sympathoinhibitory action of rilmenidine relates more to the interaction with imidazoline receptors than alpha 2-adrenoceptors.
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