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  • Title: Manipulation of allograft immunogenicity by pretreatment of cadaver donors.
    Author: Guttmann RD.
    Journal: Urol Clin North Am; 1976 Oct; 3(3):475-90. PubMed ID: 790729.
    Abstract:
    The experimental basis forming the rationale for the reduction of allograft immunogenicity prior to transplantation is described. This is based on the hypothesis that ""passenger leucocytes'' are a major immunogenic stimulus in rejection. Donor pretreatment with high doses of methylprednisolone and cyclophosphamide can be used clinically for cadaver donor pretreatment and when combined with an adequate post-transplant chemical immunosuppressive regimen results in an important in improvement in overall results as seen in a series followed for 5 1/2 years.
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