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  • Title: Different sensitivity of alpha 2A-C10 and alpha 2C-C4 receptor subtypes in coupling to inhibition of cAMP accumulation.
    Author: Jansson CC, Savola JM, Akerman KE.
    Journal: Biochem Biophys Res Commun; 1994 Mar 15; 199(2):869-75. PubMed ID: 7907869.
    Abstract:
    Two human alpha 2-adrenergic receptor subtypes, alpha 2A-C10 and alpha 2C-C4, were compared with respect to their ability to inhibit stimulated cAMP-production. The inhibition was transduced with about one order of magnitude higher sensitivity in the alpha 2C-C4 subtype than in the alpha 2A-C10 subtype. The phorbol ester, TPA, known to desensitize alpha 2-adrenergic receptor function, possible through phosphorylation of Gi, almost completely abolished the inhibition of cAMP-production in the alpha 2C-C4 subtype, while only a partial effect was seen in the alpha 2A-C10 subtype. These results suggest that the receptor subtypes differ with respect to their coupling efficiency to adenylyl cyclase.
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