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  • Title: Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures.
    Author: Hynes MA, Poulsen K, Armanini M, Berkemeier L, Phillips H, Rosenthal A.
    Journal: J Neurosci Res; 1994 Jan; 37(1):144-54. PubMed ID: 7908342.
    Abstract:
    Parkinson's disease is a prevalent neurological disease characterized by profound and incapacitating movement disorders. A common pathology in Parkinson's patients is degeneration of substantia nigra dopaminergic neurons that innervate the striatum and a corresponding decrease in striatal dopamine content. We now report that NT-4/5 can prevent the death of rat embryonic substantia nigra dopaminergic neurons in low density, enriched, primary cultures. Furthermore, these neurons express messenger RNA encoding the trkB receptor for NT-4/5 and transcripts for NT-4/5 are present in their environment. In addition, we demonstrate that NT-4/5 protects embryonic dopaminergic neurons from the toxic effects of the neurotoxin MPP+. Thus, NT-4/5 could be a physiological survival factor for midbrain dopaminergic neurons and may be useful as a therapeutic agent for Parkinson's disease.
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