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  • Title: Paclitaxel (Taxol) in breast cancer.
    Author: Arbuck SG, Dorr A, Friedman MA.
    Journal: Hematol Oncol Clin North Am; 1994 Feb; 8(1):121-40. PubMed ID: 7908664.
    Abstract:
    Paclitaxel (Taxol) is a diterpine plant compound that was isolated initially from the bark of the western yew tree, Taxus brevifolia, but can now be produced by semisynthesis from a renewable source. Paclitaxel is the first new agent in the past decade to have confirmed single agent activity in breast cancer in excess of 50%. A 28% response rate has been reported in doxorubicin-refractory patients. Ongoing studies include attempts to combine paclitaxel with other drugs used for breast cancer treatment and with radiation.
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