These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pigs.
    Author: Ortiz JL, Cortijo J, Vallés JM, Bou J, Morcillo EJ.
    Journal: J Pharm Pharmacol; 1993 Dec; 45(12):1090-2. PubMed ID: 7908981.
    Abstract:
    Rolipram (0.1-1000 micrograms kg-1, i.v.) reduced the increase in microvascular permeability induced by platelet-activating factor (PAF; 50 ng kg-1, i.v.) at different sites of the guinea-pig airways. Rolipram (1-100 micrograms kg-1, i.v.) inhibited histamine (30 micrograms kg-1, i.v.)- and bradykinin (0.3 micrograms kg-1, i.v.)-induced airway microvascular leakage. These effects of rolipram were obtained at doses which inhibit histamine (7-20 micrograms kg-1 min-1)-induced bronchoconstriction (IC50 = 3 +/- 1 micrograms kg-1, i.v.) without depressing arterial blood pressure in the guinea-pig. Aminophylline (50 mg kg-1) did not change the effect of PAF. The anti-exudative effect of rolipram is of potential therapeutic value in asthma.
    [Abstract] [Full Text] [Related] [New Search]