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  • Title: CD7, CD4 and myeloid antigen-positive acute lymphoblastic leukemia.
    Author: Nakase K, Kita K, Sekine T, Otsuji A, Shirakawa S, Tsuji K, Miyanishi E, Asou H, Kamada N.
    Journal: Int J Hematol; 1993 Dec; 59(1):41-6. PubMed ID: 7909241.
    Abstract:
    We report a case of acute lymphoblastic leukemia (ALL, FAB-L2) with unique cellular characteristics. Leukemic cells were negative for various cytochemical stainings except acid phosphatase. Immunophenotypic studies revealed CD7+, CD4+, CD8-, CD2+, CD3-, CD13+, CD25+, CD33+ and CD34+. The immunoglobulin heavy chain and T-cell receptor beta, gamma and delta chain genes were germline configurations. This patient had a karyotype of complex abnormalities involving Nos. 5 and 7. Leukemic cells showed a prominent response to interleukin-3, granulocyte macrophage colony stimulating factor (GM-CSF) and G-CSF with partial granulocytic differentiation in a colony assay. A binding assay confirmed the presence of both high and low affinity receptors for GM-CSF. These findings suggest that CD7+CD4+CD8-CD3- putative T-cell precursors may retain the capacity to differentiate to myeloid lineage.
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