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  • Title: Enhancement of CDP-DG:inositol transferase activity in src- and erbB2-transformed cells.
    Author: Imoto M, Taniguchi Y, Fujiwara H, Umezawa K.
    Journal: Exp Cell Res; 1994 May; 212(1):151-4. PubMed ID: 7909754.
    Abstract:
    Phosphatidylinositol (PI) synthesis was activated in Rous sarcoma virus-infected NIH3T3 or activated erbB2-transformed NIH3T3 cells. The in vitro activity of CDP-DG:inositol transferase prepared from these cells was also higher than that from normal parent NIH3T3 cells, although phospholipase C and PI kinase activities were not significantly different among these cells. A tyrosine kinase inhibitor, erbstatin, inhibited the PI synthesis in cultured cells, suggesting that Src and ErbB2-associated tyrosine kinases are involved in activation of CDP-DG:inositol transferase in these cell lines.
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