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  • Title: Inhibition of gastric alcohol dehydrogenase activity by histamine H2-receptor antagonists has no influence on the pharmacokinetics of ethanol after a moderate dose.
    Author: Mallat A, Roudot-Thoraval F, Bergmann JF, Trout H, Simonneau G, Dutreuil C, Blanc LE, Dhumeaux D, Delchier JC.
    Journal: Br J Clin Pharmacol; 1994 Feb; 37(2):208-11. PubMed ID: 7910473.
    Abstract:
    Ethanol undergoes gastric first pass metabolism by alcohol dehydrogenase (ADH). We have shown that cimetidine and famotidine both cause competitive inhibition of human gastric ADH in vitro. However, in a randomized 4-way cross-over study in 12 healthy subjects a 7-day course of treatment with cimetidine (800 mg day-1), ranitidine (300 mg day-1) or famotidine (40 mg day-1), did not modify the pharmacokinetics of ethanol given as a post-prandial 0.3 g kg-1 dose. We conclude that gastric mucosal concentrations of histamine H2-receptor blockers achieved after oral dosing are probably too low to cause significant inhibition of gastric ADH in vivo.
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