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  • Title: Excitatory interactions between glutamate receptors and protein kinases.
    Author: Soderling TR, Tan SE, McGlade-McCulloh E, Yamamoto H, Fukunaga K.
    Journal: J Neurobiol; 1994 Mar; 25(3):304-11. PubMed ID: 7910847.
    Abstract:
    One of the most active areas of neurobiology research concerns mechanisms involved in paradigms of synaptic plasticity. A popular model for cellular learning and memory is long term potentiation (LTP) in hippocampus. LTP requires postsynaptic influx of Ca2+ which triggers multiple biochemical pathways resulting in pre- and postsynaptic mechanisms enhancing long term synaptic efficiency. This article focuses on an acute postsynaptic mechanism that can enhance responsiveness of glutamate receptors. Evidence is presented that calcium/calmodulin-dependent protein kinase II, the major postsynaptic density protein at excitatory glutaminergic synapses, can phosphorylate glutamate receptors and enhance ion current flowing through them.
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