These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Reduced streptozotocin-induced insulitis in CD-1 mice by treatment with anti-intercellular adhesion molecule-1 and anti-lymphocyte function associated antigen-1 monoclonal antibodies together with lactic dehydrogenase virus infection.
    Author: Hayashi T, Hashimoto S, Kameyama Y.
    Journal: Int J Exp Pathol; 1994 Apr; 75(2):117-21. PubMed ID: 7911033.
    Abstract:
    Multiple low-dose streptozotocin (SZ)-induced insulitis is an animal model for insulin-dependent diabetes mellitus characterized by a mononuclear cell infiltration. SZ-induced insulitis and blood glucose concentrations were reduced by treatment with anti-intercellular adhesion molecule-1(ICAM-1) and anti-lymphocyte function associated antigen-1 (LFA-1) monoclonal antibodies. This suppressing effect was also seen in mice infected with lactic dehydrogenase virus (LDV). These results suggest that the expression of ICAM-1 in islets and LFA-1 on mononuclear cells may be important in the development of SZ-induced insulitis. The suppressive effect of LDV infection on the development of insulitis is discussed.
    [Abstract] [Full Text] [Related] [New Search]