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  • Title: [Induction of autoantibodies to serotonin and catecholamines in chronically morphine addicted rats with manifestations of abstinence syndrome].
    Author: Basharova LA, Evseev VA, Vetrilé LA, Trekova NA, Gamaleia NB, Veretinskaia AG, Tronnikov SI.
    Journal: Biull Eksp Biol Med; 1993 May; 115(5):469-71. PubMed ID: 7913839.
    Abstract:
    The possibility of formation of autoantibodies to neurotransmitters has been studied in experimental model of opiate addiction. Chronic treatment of rats with morphine that leads to formation of dependence, causes induction of antibodies to norepinephrine, dopamine and serotonin. The latter could be considered as indicators of impaired neurotransmitter metabolism. Induction of autoantibodies to neurotransmitters could be a sort of defence mechanism in opiate addiction.
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