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  • Title: The computer-assisted morphological classification of acute leukemia. I. Preliminary results.
    Author: Necheles TF, Brenner JF, Fristensky R, Neurath PW.
    Journal: Biomedicine; 1976 Sep 30; 25(7):241-4. PubMed ID: 791388.
    Abstract:
    The morphology of leukemic lymphoblasts, as seen in the initial routine bone marrow aspirate, of 40 children with ALL has been evaluated using a computer-assisted automated microscope. A statistic, derived from a combination of the number of macrolymphoblasts and the percentage of cells with no cytoplasm was found to predict response to standard therapy and to identify patients with a high probability of long-term remission as well as a group with a relatively poor response to therapy.
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