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  • Title: [Effect of insulin and adrenaline on the activity of enzymes of glutathione metabolism and glutathione concentration in rat organs].
    Author: Kolesnichenko LS, Kulinskiĭ VI, Ias'ko MV, Pensionerova GA, Grudinina IuV.
    Journal: Probl Endokrinol (Mosk); 1994; 40(3):42-4. PubMed ID: 7915418.
    Abstract:
    Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia.
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