These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Nociceptive modulation during intravenous anesthesia].
    Author: Vandermeulen EP, White PF.
    Journal: Cah Anesthesiol; 1994; 42(1):71-84. PubMed ID: 7915638.
    Abstract:
    The surgical stress can be defined as a complex array of neuroendocrine, haemodynamic, metabolic and inflammatory changes following surgical injury. These responses, when excessive, may contribute to increased postoperative morbidity and mortality. Thus a major endpoint of general anaesthesia is to protect the patient against the noxious stress response components. The different classes of anaesthetic or associated drugs are reviewed in this respect: sedative/hypnotics (barbiturates, etomidate, propofol, benzodiazepines), opioids, alpha-2 adrenergic agonists (clonidine), non-steroidal antiinflammatory drugs, intravenous local anaesthetics. Central and peripheral sensitization phenomenons--ie the sympathoadrenal response to surgery--might likely be efficiently attenuated by preemptive analgesia, and/or well-designed computer-guided total intravenous anaesthesia. 119 references complete this review.
    [Abstract] [Full Text] [Related] [New Search]