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  • Title: Structural and functional characterization of the rod outer segment membrane guanylate cyclase.
    Author: Goraczniak RM, Duda T, Sitaramayya A, Sharma RK.
    Journal: Biochem J; 1994 Sep 01; 302 ( Pt 2)(Pt 2):455-61. PubMed ID: 7916565.
    Abstract:
    In the vertebrate photoreceptor cell, rod outer segment (ROS) is the site of visual signal-transduction process, and a pivotal molecule that regulates this process is cyclic GMP. Cyclic GMP controls the cationic conductance into the ROS, and light causes a decrease in the conductance by activating hydrolysis of the cyclic nucleotide. The identity of the granylate cyclase (ROS-GC) that synthesizes this pool of cyclic GMP is unknown. We now report the cloning, expression and functional characterization of a DNA from bovine retina that encodes ROS-GC.
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