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  • Title: The fission yeast cdc18+ gene product couples S phase to START and mitosis.
    Author: Kelly TJ, Martin GS, Forsburg SL, Stephen RJ, Russo A, Nurse P.
    Journal: Cell; 1993 Jul 30; 74(2):371-82. PubMed ID: 7916658.
    Abstract:
    Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.
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