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  • Title: Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm.
    Author: Doyle DJ, Henderson LA, LeJeune FE, Miller RH.
    Journal: Arch Otolaryngol Head Neck Surg; 1994 Nov; 120(11):1273-6. PubMed ID: 7917213.
    Abstract:
    A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.
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