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  • Title: Kinetics of the early insulin response of the perfused rat pancreas to various metabolites and tolbutamide.
    Author: Vague P, Ramahandridona G, Di Campo-Rougerie C, Mahmoud F.
    Journal: Diabete Metab; 1975 Sep; 1(3):185-9. PubMed ID: 791726.
    Abstract:
    The collection every 15 seconds of the portal effluent of the isolated and perfused rat pancreas permitted the following observations: while the insulin response to tolbutamide (250 or 125 mug/ml) occurred immediately, that to glucose (15 mM), or to 1-leucine (15 mM) was delayed by 60-90 seconds. The response to d-glyceraldehyde occurred slightly but significantly more quickly than that of glucose. The response to alpha-keto-isocaproate was an intense and immediate one. Isovalerate elicited no insulin discharge. These results suggest that d-glucose and l-leucine have to be metabolized to stimulate insulin secretion and that alpha-keto-isocaproate seems to be a direct and specific signal.
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