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  • Title: Decreased in vitro megakaryocyte colony formation in chronic idiopathic thrombocytopenic purpura.
    Author: Abgrall JF, Berthou C, Sensebé L, Le Niger C, Escoffre M.
    Journal: Br J Haematol; 1993 Dec; 85(4):803-4. PubMed ID: 7918047.
    Abstract:
    In vitro megakaryocyte colony formation was studied in 25 patients with chronic idiopathic thrombocytopenic purpura (ITP), and compared to 16 controls. A significantly lower number of megakaryocyte progenitors (CFU-MK) was observed in patients (10.8 +/- 12.0 CFU-MK per 10(5) bone-marrow non-adherent mononuclear cells (NAMC), compared to controls (22.5 +/- 15.4 CFU-MK); P < 0.002. Only six patients had a normal number of CFU-MK. The number of CFU-MK was not correlated to initial platelet count (P = 0.35). These findings indicate that in vitro CFU-MK could be of interest in the diagnosis of chronic ITP, and also could be predictive for chronicity in patients with acute ITP.
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