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  • Title: Apoptosis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
    Author: Atencia R, García-Sanz M, Unda F, Aréchaga J.
    Journal: Exp Cell Res; 1994 Oct; 214(2):663-7. PubMed ID: 7925658.
    Abstract:
    In this work we have characterized a process of cell death by apoptosis occurring in retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Morphological changes corresponding to apoptosis were observed concomitantly with those of differentiated phenotype, in cell cultures treated for 48 h with physiological concentrations of all-trans-retinoic acid. Internucleosomal DNA fragmentation was also detected using agarose gels. These observations show that retinoic acid can induce both differentiation and apoptosis in an experimental system--the teratocarcinoma stem cell lines--widely used so far in the study of differentiation. We present this system as a tool for a better understanding of the role of retinoic acid in the regulation of cell differentiation and programmed cell death.
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