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  • Title: Cytoplasmic retinal localization of an evolutionary homolog of the visual pigments.
    Author: Pandey S, Blanks JC, Spee C, Jiang M, Fong HK.
    Journal: Exp Eye Res; 1994 May; 58(5):605-13. PubMed ID: 7925698.
    Abstract:
    A rhodopsin-related protein is preferentially expressed at high levels in retinal pigment epithelium (RPE) and in Müller cells. The putative RPE-retinal G protein-coupled receptor (RGR) was localized in light-adapted bovine retina by means of electron microscopic immunocytochemistry. In the RPE, the protein was localized to a widespread intracellular compartment. Except for the region adjacent to the basal surface, the RPE cytoplasm was labeled throughout the cell including the apical surface. In Müller cells also RGR was found in the intracellular compartment, especially in the cytoplasm in the region of the Müller cell endfeet and proximal cell processes. Subcellular fractionation studies of bovine RPE and neural retina indicated that RGR is a membrane-bound protein. The intracellular localization of RGR is a unique variation in the subcellular distribution of seven-transmembrane-domain receptors and suggests an unconventional role for RGR in the signal transduction process.
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