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  • Title: Photoprotection of normal human hematopoietic progenitors by the tetrapeptide N-AcSDKP.
    Author: Coutton C, Guigon M, Bohbot A, Ferrani K, Oberling F.
    Journal: Exp Hematol; 1994 Oct; 22(11):1076-80. PubMed ID: 7925774.
    Abstract:
    The tetrapeptide AcSDKP (Ser-Asp-Lys-Pro) is a reversible inhibitor of normal human hematopoietic progenitor growth. In this paper, we report that preincubation of bone-marrow mononuclear cells (MNC) with AcSDKP at 10(-10) M for 20 hours protects the granulocyte-macrophage colony-forming unit (CFU-GM) progenitors against photofrin II-mediated phototherapy. This protective effect was observed after short-term exposure to photofrin (2.5 micrograms/mL) and irradiation by high-energy doses at 514 nm. Nevertheless, AcSD-KP, which has no effect on leukemic cell proliferation, does not protect the HL-60 and K-562 leukemic cell lines against photosensitization.
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