These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A unique biosynthetic pathway for gangliosides exists in Xenopus laevis oocytes.
    Author: Hidari KI, Nagai Y, Sanai Y.
    Journal: FEBS Lett; 1994 Oct 10; 353(1):25-8. PubMed ID: 7926015.
    Abstract:
    It was previously reported that monosialosylgangliopentaosyl ceramide (GalNAc-GM1b) was a major ganglioside in Xenopus laevis oocytes. Here we determined biosynthetic pathways for the ganglioside by detailed measurements of glycosyltransferase activities. CMP-NeuAc:asialo-GM1 alpha 2-3 sialyltransferase (alpha 2-3 ST) and UDP-GalNAc:GM1b beta 1-4 N-acetylgalactosaminyltransferase (beta 1-4 GalNAcT) exhibited much higher activity than CMP-NeuAc:GalNAc-GA1 alpha 2-3 ST and UDP-GalNAc:asialo-GM1 beta 1-4 GalNAcT, respectively. These observations indicated the existence of a unique biosynthetic pathway in the oocytes as follows; asialo-GM1-->GM1b-->GalNAc-GM1b.
    [Abstract] [Full Text] [Related] [New Search]