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  • Title: Stimulation of calcium sequestration by mezerein, a protein kinase C activator, in saponized rabbit platelets.
    Author: Nishio H, Ikegami Y, Segawa T, Nakata Y.
    Journal: Gen Pharmacol; 1994 May; 25(3):413-6. PubMed ID: 7926583.
    Abstract:
    1. The saponin-permeabilized platelet was used to examine the effect of mezerein, a moderate activator of protein kinase C (C-kinase), on the sequestration of Ca2+ to its intracellular storage sites. 2. We found that the activation of C-kinase by mezerein causes the potentiation of the Ca2+ sequestration. 3. It was suggested that C-kinase in platelets might function as a negative feedback regulator for the agonist-induced Ca2+ mobilization and might be involved in its oscillation.
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