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  • Title: [Effect of traditional Chinese medicine (dai-saiko-to) on experimental calcinosis].
    Author: Goto M, Hayashi M, Seyama Y, Yamashita S.
    Journal: Nihon Yakurigaku Zasshi; 1994 Aug; 104(2):85-9. PubMed ID: 7927072.
    Abstract:
    To clarify the anti-calcinosis actions of traditional Chinese medicine (Dai: Dai-saiko-to) and estradiol benzoate (E2), 7-week or retired (about 6-months-old) female rats were treated with Vit. D2 (1.75 x 10(5) I.U./kg b.w./day) for 4 days, and then were fed a basal diet containing Dai (at ten times the medical dose in humans) or were injected i.p. with E2 (at the medical dose in humans) for 6 weeks. The following results were obtained: 1) Dai did not improve Ca and P metabolism in experimental calcinosis of 7-week female rats; 2) in retired female rats, Dai decreased both P in the heart and the ratio of Ca to P in bone, similar to the treatment with E2. Dai, as well as E2, seemed to nomalize Ca and P metabolism disturbed by Vit. D2 treatment.
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