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Title: Risk factors for genital papillomavirus infection in populations at high and low risk for cervical cancer. Author: Reeves WC, Gary HE, Johnson PR, Icenogle JP, Brenes MM, de Britton RM, Dobbins JG, Schmid DS. Journal: J Infect Dis; 1994 Oct; 170(4):753-8. PubMed ID: 7930714. Abstract: This study sought to determine risk factors for genital infection with papillomavirus (HPV) in Panamanian women 20-49 years old. Subjects were randomly selected from Herrera and Panama provinces (cervical cancer incidence 79 and 25/100,000, respectively). Participants were interviewed to determine sexual behavior. Cervicovaginal lavage specimens were obtained to test for HPV DNA by commercial dot blot hybridization. HPV-16/18 DNA was detected significantly more frequently (5%) in Panama than Herrera (2%) samples (P = .002). Clearly, infection with high-risk HPV types alone cannot account for the differences in cervical cancer incidence between the two populations. HPV-16/18 detection decreased with increasing years of sexual experience among all women in Panama and among women with multiple partners in Herrera. However, HPV-16/18 detection did not change with sexual experience among monogamous women in Herrera. Thus, the epidemiology of HPV is complex and reflects both virus- and population-specific factors.[Abstract] [Full Text] [Related] [New Search]