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  • Title: Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B.
    Author: Fernández García C, Marco JL, Fernández-Alvarez E.
    Journal: J Neural Transm Suppl; 1994; 41():287-90. PubMed ID: 7931239.
    Abstract:
    A new series of thirty derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines has been synthesized and the compounds assayed as inhibitors of MAO-A and MAO-B from bovine brain mitochondria. IC50 values for both isoenzymes were determined using tyramine as a common substrate. Structure-activity and selectivity relationships are discussed.
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