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  • Title: [Suppressive effect of methylparaben on the evoked compound action potentials in excised rabbit cervical vagus nerve].
    Author: Mizuno K, Ogawa S, Itoh S.
    Journal: Masui; 1994 Jul; 43(7):1008-14. PubMed ID: 7933466.
    Abstract:
    We evaluated the effects of methylparaben on rabbit vagus nerve by measuring the amplitudes and latencies of the evoked compound action potentials during incubation in 0.1% methylparaben containing Ringer's bicarbonate solution. We also evaluated the histological changes of the nerves after incubation in methylparaben-RB solution by means of the electron microscopy. We found that 0.1% methylparaben caused complete suppression of the compound action potentials, which recovered completely after washing in methylparaben-free RB solution. The electron microscopic studies revealed no histological changes of nerves incubated in 0.1% methylparaben containing RB solution. We conclude that methylparaben suppresses nerve excitability dose-dependently, but does not destroy nervous tissues in concentrations up to 0.1%.
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