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  • Title: [Bone marrow transplantation for a patient with ALL from her 75-year-old mother using cryopreserved bone marrow cells].
    Author: Uike N, Suehiro Y, Takahira H, Shimada Y, Nagatoshi Y, Ikuno Y, Okamura J, Tasaka H, Miyamura T, Ishikura H.
    Journal: Rinsho Ketsueki; 1994 Aug; 35(8):801-3. PubMed ID: 7933569.
    Abstract:
    We report a 42-year-old woman with acute lymphoblastic leukemia who received allogeneic bone marrow transplantation (BMT) in the first remission from her 75-year-old, HLA-identical, MLC-non-reactive mother. Considering the difficulty to obtain a sufficient number of bone marrow cells from such an old donor, we harvested the cells (2.31 x 10(8)/kg) on day -37 and cryopreserved them until use. BMT was performed on June 3rd, 1993 after conditioning regimen with total body irradiation, high-dose AraC and cyclophosphamide. Graft-versus-host disease (GVHD) prophylaxisis was attempted by cyclosporin A and short-term methtrexate. Her hematopoietic recovery was favorable with no signs and symptoms of GVHD as far as day 218.
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