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  • Title: [Development of new drugs for intractable vasculitis--lipo-PGE1 and monoclonal antibody].
    Author: Matsuda T, Hoshi K, Igarashi R, Ichikawa Y.
    Journal: Nihon Rinsho; 1994 Aug; 52(8):2187-91. PubMed ID: 7933610.
    Abstract:
    "Lipo-PGE1", PGE1 incorporated into lipid microspheres (LM), has marked antiplatelet and vasodilatory actions. Since LM largely accumulate in inflamed vascular lesions, lipo-PGE1 shows a marked efficacy for treating vascular diseases such as atherosclerosis and vasculitis. Another recently developed drugs against intractable vasculitis are monoclonal antibodies to surface antigens of lymphocytes. Treatment with humanized anti-CDw52, and subsequent anti-CD4 monoclonal antibodies was reported to have brought remission up to 42 months.
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