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  • Title: Changes in the male rat hepatic cytochrome P-450 level, heme oxygenase and delta-aminolevulinic acid synthase activities at various stages of life.
    Author: Plewka A, Bienioszek M, Plewka D.
    Journal: Mech Ageing Dev; 1994 May; 74(1-2):79-88. PubMed ID: 7934210.
    Abstract:
    delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers at various stages of life. We tried to investigate the spontaneous phases of these enzymatic protein activities and the levels of cytochrome P-450 as a function of age. We noted that each of these proteins change their activity and level very characteristically during the rats' lifetime. However, correlations between heme oxygenase activity, delta-aminolevulinic acid synthase activity and cytochrome P-450 levels still need to be investigated to elucidate the mechanism of these connections.
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