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  • Title: Role of rpoS (katF) in oxyR-independent regulation of hydroperoxidase I in Escherichia coli.
    Author: Ivanova A, Miller C, Glinsky G, Eisenstark A.
    Journal: Mol Microbiol; 1994 May; 12(4):571-8. PubMed ID: 7934880.
    Abstract:
    We present evidence showing that rpoS (katF) is a regulator of katG gene transcription in an oxyR-independent manner. Mutation of the rpoS gene in several different Escherichia coli strains caused a significant reduction in catalase HPI activity. In rpoS-delta oxyR double mutants, the level of HPI was considerably lower compared to the delta oxyR parent strain, and was restored when transformed with an rpoS+ plasmid. Overproduction of HPI in oxyR- suppressor strains was greatly diminished after inactivation of the rpoS gene and was accompanied by a substantial increase in sensitivity to menadione. Beta-galactosidase expression from a katG::lacZ promoter was lower in rpoS strains compared to rpoS+ isogenic parents. Several delta oxyR strains had detectable levels of katG transcription that was significantly diminished after rpoS gene inactivation.
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