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  • Title: [Vigabatrin: results with a new antiepileptic agents in 57 patients in a general neurological practice].
    Author: van der Zwan A, van der Zwan A.
    Journal: Ned Tijdschr Geneeskd; 1994 Sep 10; 138(37):1859-63. PubMed ID: 7935922.
    Abstract:
    OBJECTIVE: To obtain answers to the following questions: can vigabatrin replace other anti-epileptics? Is it feasible to use VGB as a monotherapy? DESIGN: Retrospective, descriptive. SETTING: Neurological outpatient clinic of the Sophia Hospital in Zwolle, the Netherlands. METHOD: In 57 of the 492 (28 men, 29 women) patients suffering from epilepsy who had been treated for more than 1 year, VGB (500-4000 mg/day) was added to the regimen because of persistent attacks (n = 21), adverse effects of other medication (n = 14) or both (n = 22). Mean age was 45 years (3-77). In the end, 17 patients were treated with VGB alone. The average frequencies of attacks and the adverse effects before and after start of VGB treatment were compared. RESULTS: Almost all patients who had suffered from partial attacks became attack-free, as well as the majority of patients with generalised tonic-clonic attacks or a combination of these with partial attacks. In 5 patients from this group a status epilepticus occurred. The patients with infantile spasms became attack-free. Drowsiness and headache were the most frequent side-effects. Psychosis occurred in one patient. Eventually 11 of the 17 patients on VGB monotherapy became attack-free. CONCLUSIONS: Adding VGB to the original AE, but also partial or full replacement of other AE by VGB in therapy-resistant epilepsy, can make a number of patients attack-free. This applies in particular to patients with partial epileptic attacks and infantile spasms.
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